Our Total Iron Binding Capacity (TIBC) Test includes an Iron Test and is used to see if there is too much or too little iron in the blood. Iron moves through the blood attached to a protein called transferrin. The TIBC Test is often used to differentiate between anemia types and gives more iron statistics than the Iron Test alone.
Disorders of iron homeostasis rank among the most common of human diseases. These include states of either iron deficiency (inadequate adsorption or increased loss) or iron overload (normal erythropoiesis but iron exceeds iron binding capacity of transferrin or catabolism of red cells causes iron overload). Serum iron levels fluctuate considerably in response to various pathologic as well as physiologic conditions, and as such, require additional studies to assess a patient's iron status. Blood levels for iron, total iron binding capacity (TIBC), and Ferritin facilitate interpretation.
Iron is transported in the blood by transferrin (essentially all circulating iron is bound to transferrin). The TIBC is the amount of iron needed to 100% saturate transferrin (thus an indirect measurement of transferrin). The assay for iron measures the amount of iron which is bound to transferrin.